Feasibility study into LPHS

Dr. Bhanu Prasad and his research team are conducting a feasibility study of a randomized controlled trial investigating renal denervation as a possible treatment option in patients with Loin Pain Hematuria Syndrome (LPHS). Dr. Prasad presented this study at the CNTN meeting in November 2019 in Washington, D.C and we look forward to hearing more about the study at future CNTN meetings.

Loin Pain Hematuria Syndrome (LPHS) is a poorly understood clinical condition characterized by severe pain localized to the kidney but in the absence of identifiable urinary tract disease. Case reports/series have shown renal denervation via catheter-based radiofrequency ablation to be an effective therapeutic option for the treatment of LPHS. To determine whether catheter-based renal denervation is a meaningful addition to the treatment options in these often difficult to treat LPHS patients, a randomized clinical trial is needed. Prior to conducting a definitive trial that focuses on patient outcomes, ensuring the feasibility of undertaking such a trial is required. As such, we will conduct a single-centre randomized control feasibility trial designed to determine viability and provide framework and direction for a larger trial.

The research team will conduct a double-blinded, parallel-group, partial crossover, sham-controlled, randomized feasibility trial on 10 LPHS patients at the Regina General Hospital, Saskatchewan. Participants will be randomized into either renal denervation (treatment group) or a sham treatment (control group). Data (pain, quality of life, mood, disability) will be collected from both groups at baseline, 6 weeks, 3 and 6 months after the intervention. After the initial 6-month follow-up is over, the participants who received the sham procedure will cross over into the treatment group and will be followed for an additional 6 months in the same manner as the treatment group.

The lessons learnt from this trial will lay the framework and direction for conducting a multi-site randomized controlled trial involving a larger cohort of patients.

CSN e-Poster available for viewing

On behalf of the network, an abstract was submitted and accept for the CSN annual general meeting entitled, “A New Vision for Nephrology Trials in Canada” . The meeting was cancelled but the poster was submitted and can be found on the Can-SOLVE CKD website and the CSN poster website.

As part of the Can-SOLVE CKD virtual network update, a short 7-minute presentation was given by Alicia Murdoch, the CNTN coordinator. You can view the recording of the presentation here.

CNTN represented on CSN Board of Directors

The Canadian Society of Nephrology (CSN) announced their new president and board of directors today. We are pleased to share that 3 CNTN committee members are on the new board.

Rita Suri, member of the Scientific Operations and Executive committees, will be the chair of the CSN Scientific committee.




Amber Molnar, co-chair of the Communications and Engagement committee, will be representing the province of Ontario on the CSN board.




Bhanu Prasad, member of the Communications and Engagement committee, will be the chair of the CSN Community Nephrology committee.




Congratulations to everyone who was elected to the board.

COVID-19 Related Trials Listing

Below is a list of COVID-19 specific study websites and websites with study lists.  As the number of COVID-19 related studies increases, we will do our best to keep this page updated.

  • Health care workers and those living with COVID-19 positive people in Alberta, Manitoba and Quebec are eligible to participate in a trial of post-exposure prophylaxis at http://covid-19research.ca
  • COVID-19-COS project brings together patients, the public and health professionals to identify, prioritise and agree on the most important outcomes for research in COVID-19. Round 1 is planned to close on April 10, visit https://www.covid-19-cos.org/ to participate.
  • COVID-19 Resources Canada lists ongoing Canadian trials that can be sorted by Principal Investigator, Institution or Research Category.

Active Canadian trials listed on ClinicalTrials.gov can be found here.

COVID-19 Trial Management Resources

As the COVID-19 pandemic continues, most hospitals have halted all non-emergency visits, greatly affecting the conduct of clinical trials. Below are links to both Health Canada and the US Food and Drug Administration (FDA) guidance on the management of clinical trials during this time, as well as various Canadian research organizations. This post will be updated as more resources come to our attention.

We are working to collect a list of trial resources to help trialist overcome challenges and keep their research program moving forward. If you have had success or suggestions that you can share, please email amurdoch@cansolveckd.ca.

Canadian Institutes for Health Research FAQs on Impact of COVID-19 – https://cihr-irsc.gc.ca/e/51917.html#faq

Health Canada Guidance on Management of Clinical Trials during the COVID-19 pandemic – https://www.canada.ca/en/health-canada/services/drugs-health-products/drug-products/announcements/management-clinical-trials-during-covid-19-pandemic.html

US FDA Guidance for Clinical Trials during COVID-19 – https://www.fda.gov/media/136238/download

COVID-19 Resources Canada – https://covid19resources.ca/activeresearch.html

Clinical Trials Ontario –  https://www.ctontario.ca/covid-19-clinical-trial-resources/

Clinical Trials BC – https://www.clinicaltrialsbc.ca/updates-for-clinical-trials-bc-regarding-covid-19/

Canadian Institute of Health Information (CIHI)  – https://www.cihi.ca/en/covid-19-resources

Spring Meeting Cancelled

In response to the current situation and in light of the cancellation of the CSN Annual General Meeting, we will be cancelling the 2020 CNTN Spring Meeting in order to maintain the health and well-being our team, our members, and the community at large. If you have any questions, please contact Alicia Murdoch at amurdoch@cansolveckd.ca.

We thank you for your patience and continued support as we navigate this challenging, and unprecedented, situation.

Budgeting for Patient Engagement

The George & Fay Yee Centre for Healthcare Innovation (CHI) in Winnipeg Manitoba has developed a budget builder tool to help investigators create budgets for patient engagement. This comprehensive document includes cost lines for travel, compensation, care-giving, audio-visual, facilitator, interpretators and more. The Excel file can be downloaded here and there is also a blog post about using this tool.

Ready for Review?

The Scientific Operations Committee is always accepting proposals for peer review and it is now easier than ever to submit your proposal. Click on the Peer Review tab on the home page or here and you will be taken to a page with all the information as well as an online submission form. You will receive confirmation of your submission and Alicia will contact you with the review date when assigned.

The committee has also created a new initiative for a more informal review process via webinar where you can get realtime comments and ask questions of researchers present. This is a great way to interact with researchers and get some early feedback on your proposal. You can submit for informal review using the online submission form on the Peer Review page.

Communications and Engagement Committee – Suggestion Box

CNTN CEC - Engagement Suggestion Box

  • All suggestions are welcome! Thank you for your participation.